Ryokan Hanare is between Hanazonocho Metro Station (6 mins' walk) and Tengachaya Station (8 mins' walk). From Hanazonocho Station, you can get to Namba, the center of Osaka's dining and nightlife district, by metro in about 10 mins. Tengachaya Station has a direct line to the airport (the Nankai-Airport line), so it's fairly easy for arrivals and departures.
The hotel is in a Shoten Gai (a shopping street under a dome) in Tennoji Ward. The neighborhood is not the most picturesque, but at night, it comes alive with Izakayas, Ramen shops, and eateries, so it's easy to eat nearby if you come back late from sightseeing.
The staff is courteous, friendly, and very helpful. There's always someone who speaks English to answer questions and give you tips.
The hotel is also pretty close to Sumiyoshi-Taisha, one of the well-known Osaka shrines.