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Hotels from €66
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Most frequently booked hotels in Defiance

Hollywood Casino & Hotel St. Louis
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The Wildwood Hotel
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Ameristar Casino Resort and Spa
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Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
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Wingate by Wyndham St. Louis/Fenton Route 66
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Days Inn and Suites by Wyndham St. Louis/Westport Plaza
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Embassy Suites by Hilton St. Louis St. Charles
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Crowne Plaza St. Louis Airport, an IHG Hotel
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Sonesta ES Suites St. Louis - Chesterfield
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La Quinta Inn & Suites by Wyndham St. Louis Westport
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Best Western Plus St. Louis West-Westport
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Baymont by Wyndham St. Charles
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Homewood Suites by Hilton St. Louis Riverport - Airport West
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Drury Plaza Hotel St. Louis St. Charles
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Hampton Inn St. Charles St. Peters
Finding Defiance Hotels
So, you're considering a trip to Defiance? If you'd like to find accommodation that's within a stone's throw of the sights, you can enter your holiday dates and then use the filters next to your hotel search results to find somewhere to stay near the area's attractions. You can choose among 20 Defiance hotels and accommodation choices to find a place you'd like to stay.
Exploring Defiance
The city of Defiance has some interesting things to see and do. Popular attractions in and around Defiance include:
- Chandler Hill Vineyards
- Sugar Creek Winery
- Historic Daniel Boone Home and Heritage Center
- August A. Busch Memorial Conservation Area
- Missouri River
- Yellow Farmhouse Winery
- Matson Hill Park Trailhead
When making plans for your holiday in Defiance, you can also use ebookers to search for a convenient flight to St. Louis, MO (SUS-Spirit of St. Louis) Airport. You can narrow down your search by number of stops, airline or departure time to identify one that works best for you.
When is the Best Time to Explore Defiance?
If you're curious when is the best time of year to visit Defiance, you may find this information about seasonal weather helpful when you are organising your getaway. The warmest months in Defiance are typically July and August, whereas the coldest months are usually January and February. The months with the most rain are May and April, whereas January and February have the least.
Here's a rundown on how much rain you can expect and what the temperatures are going to be like:
- From January to March, the average daytime temperature is 13°C and at night it is -4°C. Seasonal average rainfall is 251 mm.
- If you visit between April and June, you can expect an average temp of 30°C during the day and 8°C at night. Average rainfall during this season is 399 mm.
- The daytime average temp from July to September is 32°C and the night-time average is 17°C. Average precipitation for this season is 319 mm.
- Between October and December, the average temp during the day is 20°C and 0°C at night. Seasonal average rain is 259 mm.
- The average annual rainfall in Defiance is 1228 mm.
Defiance hotels essential information
Accommodation | 811 hotels |
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Lowest Price | €66 |
Highest Price | €214 |
Popular hotels | Hollywood Casino & Hotel St. Louis, The Wildwood Hotel, Ameristar Casino Resort and Spa, Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham, Wingate by Wyndham St. Louis/Fenton Route 66, Days Inn and Suites by Wyndham St. Louis/Westport Plaza, Embassy Suites by Hilton St. Louis St. Charles, Crowne Plaza St. Louis Airport, an IHG Hotel, Sonesta ES Suites St. Louis - Chesterfield, La Quinta Inn & Suites by Wyndham St. Louis Westport, Best Western Plus St. Louis West-Westport, Baymont by Wyndham St. Charles, Homewood Suites by Hilton St. Louis Riverport - Airport West, Drury Plaza Hotel St. Louis St. Charles, Hampton Inn St. Charles St. Peters |