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Featured Hotels near Otay Mesa

Bay Club Hotel & Marina
2131 Shelter Island Dr San Diego CA
29.22 km from Otay Mesa
The price is €114 per night
€114
4 Jan - 5 Jan 2026
includes taxes & fees
Our customers tell us they can't get enough of Bay Club Hotel & Marina's great location. During your stay, you're just a quick walk from Shelter Island. You'll find features such as free WiFi in public areas, plus an outdoor pool and a restaurant.

Sheraton San Diego Resort
1380 Harbor Island Dr San Diego CA
28.09 km from Otay Mesa
The price is €135 per night
€135
28 Dec - 29 Dec
includes taxes & fees
Our customers tell us they can't get enough of Sheraton San Diego Resort's great location. During your stay, you're just a quick walk from San Diego Bay. Free WiFi in public areas, a free round-trip airport shuttle and 3 outdoor pools are available. This property offers pet-friendly amenities, such as food and water bowls.

The DEXTRO Little Italy, BW Premier Collection
1617 1st Avenue San Diego CA
25.38 km from Otay Mesa
The price is €109 per night
€109
23 Dec - 24 Dec
includes taxes & fees
Our customers tell us that they can't get enough of the helpful staff at The DEXTRO Little Italy, BW Premier Collection. During your stay, you're just a quick walk from San Diego Civic Theatre. Features include free WiFi in public areas, plus an outdoor pool and a restaurant.

Courtyard by Marriott San Diego Downtown Little Italy
1646 Front St San Diego CA
25.5 km from Otay Mesa
The price is €130 per night
€130
30 Dec - 31 Dec
includes taxes & fees
Our customers tell us that they can't get enough of the helpful staff at Courtyard by Marriott San Diego Downtown Little Italy. During your stay, you're just a quick walk from Waterfront Park. You'll find features such as free WiFi in public areas, plus an outdoor pool and a restaurant. This property offers pet-friendly amenities, such as an off-lead area.

Lafayette Hotel & Club
2223 El Cajon Blvd San Diego CA
26.78 km from Otay Mesa
The price is €224 per night
€224
29 Dec - 30 Dec
includes taxes & fees
Our customers tell us that they can't get enough of the helpful staff at Lafayette Hotel & Club. During your stay, you'll be close to San Diego Zoo. Enjoy features like free WiFi in public areas, plus 2 restaurants and 3 bars.

Legacy Resort Hotel & Spa
875 Hotel Circle South San Diego CA
28.87 km from Otay Mesa
The price is €149 per night
€149
23 Dec - 24 Dec
includes taxes & fees
Legacy Resort Hotel & Spa's great location gets high marks from our customers. During your stay, you'll be within walking distance of Hotel Circle. Enjoy features like free WiFi in public areas, plus a full-service spa and an outdoor pool.

Hard Rock Hotel San Diego
207 5th Ave San Diego CA
24 km from Otay Mesa
The price is €208 per night
€208
23 Dec - 24 Dec
includes taxes & fees
Our customers tell us they can't get enough of Hard Rock Hotel San Diego's great location. During your stay, you're just a quick walk from Petco Park. Enjoy features like free WiFi in public areas, plus 2 restaurants and 2 coffee shops/cafes.

DoubleTree by Hilton Hotel San Diego - Mission Valley
7450 Hazard Center Dr San Diego CA
29.15 km from Otay Mesa
The price is €110 per night
€110
3 Jan - 4 Jan 2026
includes taxes & fees
Our customers tell us that they can't get enough of the helpful staff at DoubleTree by Hilton Hotel San Diego - Mission Valley. During your stay, you'll be connected to a shopping centre and within walking distance of Fashion Valley Mall. Features include free WiFi in public areas, plus an indoor pool and a restaurant.

Best Western Seven Seas
411 Hotel Circle South San Diego CA
28.73 km from Otay Mesa
The price is €73 per night
€73
23 Dec - 24 Dec
includes taxes & fees
Our customers tell us that they can't get enough of the shopping around Best Western Seven Seas. During your stay, you'll be within walking distance of Hotel Circle. Free WiFi in public areas, free self-parking and an outdoor pool are available.

Hilton San Diego Mission Valley
901 Camino Del Rio S San Diego CA
28.44 km from Otay Mesa
The price is €120 per night
€120
28 Dec - 29 Dec
includes taxes & fees
Our customers tell us that they can't get enough of the helpful staff at Hilton San Diego Mission Valley. During your stay, you'll be within walking distance of Mission Valley Mall. Features include free WiFi in public areas, plus an outdoor pool and a restaurant.

Wyndham San Diego Bayside
1355 N Harbor Drive San Diego CA
25.71 km from Otay Mesa
The price is €159 per night
€159
24 Dec - 25 Dec
includes taxes & fees
The sightseeing around Wyndham San Diego Bayside gets high marks from our customers. During your stay, you're just a quick walk from Port of San Diego. You'll find features such as free WiFi in public areas and a free round-trip airport shuttle, plus 3 restaurants.

The Dana on Mission Bay
1710 W Mission Bay Dr San Diego CA
33.74 km from Otay Mesa
The price is €154 per night
€154
23 Dec - 24 Dec
includes taxes & fees
The Dana on Mission Bay's great beach location gets high marks from our customers. During your stay, you'll be within walking distance of Mission Bay. Enjoy features like 2 outdoor pools, 2 poolside bars and a restaurant. This property offers pet-friendly amenities, such as food and water bowls.

The Sofia Hotel
150 W Broadway San Diego CA
24.93 km from Otay Mesa
Our customers tell us that they can't get enough of the helpful staff at The Sofia Hotel. During your stay, you're just a quick walk from San Diego Civic Theatre. Free WiFi in public areas, a restaurant and a 24-hour gym are available. This property offers pet-friendly amenities, such as food and water bowls.

Best Western Plus Marina Gateway Hotel
800 Bay Marina Dr National City CA
16.95 km from Otay Mesa
The price is €101 per night
€101
4 Jan - 5 Jan 2026
includes taxes & fees
Best Western Plus Marina Gateway Hotel's great location gets high marks from our customers. During your stay, you'll be within walking distance of San Diego Bay. You'll find features such as free WiFi in public areas and free self-parking, plus an outdoor pool.

Kings Inn San Diego
1333 Hotel Cir S San Diego CA
29.1 km from Otay Mesa
Our customers tell us they can't get enough of Kings Inn San Diego's great location. During your stay, you'll be within walking distance of Riverwalk Golf Club. Features include free WiFi in public areas, plus 2 restaurants and an outdoor pool.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Otay Mesa hotels essential information
Accommodation | 4,884 hotels |
|---|---|
Lowest Price | €73 |
Highest Price | €224 |
Popular hotels | Bay Club Hotel & Marina, Sheraton San Diego Resort, The DEXTRO Little Italy, BW Premier Collection, Courtyard by Marriott San Diego Downtown Little Italy, Lafayette Hotel & Club, Legacy Resort Hotel & Spa, Hard Rock Hotel San Diego, DoubleTree by Hilton Hotel San Diego - Mission Valley, Best Western Seven Seas, Hilton San Diego Mission Valley, Wyndham San Diego Bayside, The Dana on Mission Bay, The Sofia Hotel, Best Western Plus Marina Gateway Hotel, Kings Inn San Diego |
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